Yuri Kholodenko, Ph.D.



Ph.D. in Physical Chemistry, University of Pennsylvania

Courses Taught at ACPHS

General Physics I and II
Physics for Life Sciences
College Physics I and II

Research Interests

Molecular dynamics in biological processes is a challenging and exciting field of modern biophysics. I am interested in protein dynamics and the connection between protein dynamics and function. A deeper understanding of functionally significant protein motions is an important step toward the rational design of new proteins with interesting practical applications.

Selected Publications

Y. Kholodenko, M. Volk, E. Gooding, R. M. Hochstrasser. "Energy dissipation and relaxation processes in deoxy myoglobin after photoexcitation in the Soret region." Chemical Physics, 259 , 71-87, 2000.

Y. Kholodenko, E. A. Gooding, Y. Dou, M. Ikeda-Saito, R. M. Hochstrasser. "Heme protein dynamics revealed by geminate nitric oxide recombination in mutants of iron and cobalt myoglobin." Biochemistry, 38 , 5918-5924, 1999.

S. Gnanakaran, M. Lim, M. Volk, E. Gooding, Y. Kholodenko, R. M. Hochstrasser. "Chemical reaction dynamics of some simple molecules in solutions." Philos. Trans. R. Soc. London, A, 356 , 377-388, 1998.

H. S. M. Lu, M. Volk, Y. Kholodenko, E. Gooding, R. M. Hochstrasser, W. F. DeGrado. "Aminothiotyrosine disulfide, an optical trigger for initiation of protein folding." J. Am. Chem. Soc., 119 , 7173 -7180, 1997.

M. Volk, Y. Kholodenko, H. S.M. Lu, E. A. Gooding, W. F. DeGrado, R. M. Hochstrasser. "Peptide conformational dynamics and vibrational stark effects following photoinitiated disulfide cleavage." J. Phys. Chem. B, 101 , 8607-8616, 1997.

Associate Professor
Department of Basic and Social Sciences