William R. Millington, Ph.D.
Ph.D., Massachusetts Institute of Technology
Courses Taught at ACPHS
Medicinal Chemistry III and IV
Dr. Millington's research focuses on the function of opioid peptide neurons in mammalian brain and their role in pain perception, cardiovascular regulation and addiction. The ultimate goal of this research is to develop novel treatments for the adverse effects of opiate analgesics, particularly addiction.
Yilmaz MS, Millington WR, Feleder C. The preoptic anterior hypothalamic area mediates initiation of the hypotensive response induced by lipopolysaccharide in male rats. Shock 29:232-237, 2008.
Göktalay G, Cavun S, Levendusky MC, Hamilton JR, Millington WR. Glycyl-glutamine inhibits nicotine conditioned place preference and withdrawal. Eur J Pharmacol 530:95-102, 2006.
Göktalay G, Cavun S, Levendusky MC, Resch, GE, Veno, PA , Millington WR. Hemorrhage activates proopiomelanocortin neurons in the rat hypothalamus. Brain Res1070:45-55, 2006.
Millington WR, Göktalay G. Neurochemical approaches to addiction treatment. In: Smith H, Passik S, eds., Textbook, of Pain and Chemical Dependency, Oxford University Press, NY (In Press).
Cavun S, Göktalay G, Millington WR. Glycyl-glutamine, an endogenous ß-endorphin-derived peptide, inhibits morphine conditioned place preference, tolerance, dependence and withdrawal. J Pharmacol Exp Ther 315:949-958, 2005.
Cavun S, Göktalay G, Millington WR. The hypotension evoked by visceral nociception is mediated by delta opioid receptors in the periaqueductal gray. Brain Res 1019:237-245, 2004.