Lauren Purington, Ph.D.
Ph.D. University of Michigan, Pharmacology
B.S. Clarkson University, Bio-molecular Science and Chemistry
Courses Taught at ACPHS
Drugs of Abuse
Introduction to Pharmaceutical Sciences
Infectious Disease Pharmacology
Scientific Literature Evaluation
My research focuses on interactions between mu and delta opioid receptors in the production of tolerance and dependence. Using computational modeling of the mu and delta opioid receptor, I designed, synthesized, and characterized bifunctional tetra- and pentapeptides to produce ligands displaying both mu-agonism and delta-antagonism.
Anand, J.C., Purington, L.C., Pogozheva, I.D., Traynor, J.R., Mosberg, H.I. "Modulation of opioid receptor ligand affinity and efficacy using active and inactive state receptor models." Chemical Biology Drug Design, 80:763-770, 2012.
Purington, L.C., Sobczyk-Kojiro, K., Pogozheva, I.D., Traynor, J.R., Mosberg, H.I. "Development and in vitro characterization of a novel bifunctional μ-agonist/δ-antagonist opioid tetrapeptide." ACS Chemical Biology, 6(12):1375-1381, 2011.
Purington, L.C., Pogozheva, I.D., Traynor, J.R., Mosberg, H.I. "Pentapeptidesdisplaying μ-opioid receptor agonist and δ-opioid receptor antagonist/partial agonist properties." Journal of Medicinal Chemistry, 52(23): 7724-7731, 2009.
Society for Neuroscience (San Diego, CA) "Interactions between endogenous opioid receptors in SH-SY5Y cells." L.Purington, E. Levitt, H.I. Mosberg, J.R. Traynor, 2010.
Experimental Biology (New Orleans, LA) "Understanding affinity and efficacy using mixed-action opioid peptides." L.C. Purington, H.I. Mosberg, J.R. Traynor, 2009.
Honors and Achievements
University of Michigan Graduate Teaching Certificate, Rackham Graduate School and Center for Research on Learning and Teaching, Ann Arbor, MI, 2011.
Professional Organization Membership
Member of the American Society of Phamacology and Experimental Therapeutics (ASPET)
MSPS Graduate Admissions Committee