- Ph.D., University of Arizona
- Pharm.D., University of Florida
- B.S. in Pharmacy, Massachusetts College of Pharmacy
- University of Wisconsin-Madison
Quantitative Systems Pharmacology (QSP) of Brain Tumor Drug Therapy
Our lab is focused on pharmacokinetic [PK]- and pharmacodynamic [PD]-directed brain tumor chemotherapy. Under the QSP paradigm, we have incorporated systems-based methods with PK/PD methods to derive cell-type specific PK/PD and enhanced PD models that link PK and PD information at the cell and molecular scale. Ongoing projects concern anticancer drug development, drug resistance, oncometabolites, and tumor heterogeneity. The projects utilize a diverse array of in vitro and in vivo methods that allow us to build mechanistic PK/PD models of anticancer drugs that are scalable from preclinical models to patients. The ultimate objective of our work is to discover new drug treatment strategies and means to translate these therapies to patients.
RESEARCH GRANTS AS PI
- Roche Postdoc Fellowship Program: Therapeutic applications of mechanism-based PK/PD models of epigenetic modifiers.
Completed in Past Three Years
- NIH CA072937: Interactions Between Cytotoxic and Antiangiogenic Drugs [12/01/10 - 11/30/15]
- NIH CA073728: Function of the MRP Family [11/01/08 – 06/30/15]
- NIH CA127963: Development of Targeted Anticancer Drugs [7/01/08 - 04/30/14]
PREVIOUS POSITIONS OR APPOINTMENTS
- Mount Sinai School of Medicine, Department of Pharmacology and Systems Therapeutics, New York, NY
- Fox Chase Cancer Center, Philadelphia, PA
- American Association for Cancer Research (AACR)
- American Association for the Advancement of Science (AAAS)
PUBLICATIONS, HONORS, AND ACHIEVEMENTS
Q. Zhou, P. Guo, G. D. Kruh, P. Vicini, X. Wang, J. M. Gallo. Predicting human tumor drug concentrations from a preclinical pharmacokinetic model of temozolomide brain disposition. Clin. Cancer Res., 13:4271-4279, 2007.
Q. Zhou, and J.M. Gallo. The Pharmacokinetic/Pharmacodynamic Pipeline: Translating Anticancer Drug Pharmacology to the Clinic. AAPS Journal 13:111-120, 2011.
R. Iyengar, S. Zhao, S.-W. Chung, D. E. Mager and J. M. Gallo. Merging systems biology with pharmacodynamics. Science Trans. Med., 4:126ps7, 2012.
J. Sharma, H. Lv and J. M. Gallo. Intratumoral Pharmacokinetic and Pharmacodynamic Modeling of Gefitinib in a Mouse Orthotopic Glioblastoma Model. Cancer Res, 73:5242-52, 2013.
X. Zhang, M. R. Birtwistle, J. M. Gallo. Network Pharmacodynamic Model-Based Design Pipeline for Customized Cancer Chemotherapy. CPT:Pharmacometrics and Syst. Pharmacol. 3:e92, 2013.
A. Ballesta, Q. Zhou, X. Zhang, H. Lv, and J. M. Gallo. A multi-scale approach to develop cell type-specific pharmacokinetic/pharmacodynamic models: intracellular brain and brain tumor disposition of temozolomide. CPT:Pharmacometrics Syst. Pharmacol., 3, e112,2014.
HONORS AND ACHIEVEMENTS
“Target Tissue Pharmacokinetic/Pharmacodynamic Models of Anticancer Drugs: A Missing Link in Translational Medicine." The Deborah M. Richman Memorial Lectureship, MD Anderson Cancer Center, Houston, TX, May 2009.
“Preclinical Approaches to Rethink Brain Tumor Chemotherapy.” BMS Distinguished Lectureship, University at Buffalo, School of Pharmacy, May 2013.
2015 Recipient of the PSP award on behalf of CPT:Pharmacometrics and Systems Pharmacology (CPT:PSP) journal published by ASCPT.