Research


Facilities and Equipment

Albany College of Pharmacy and Health Sciences has campuses in Albany, NY, and Colchester, VT, in addition to its Pharmaceutical Research Institute in Rennselaer, NY(located 10 minutes from the main campus). Our geographic diversity mirrors the diversity of facilities and equipment available in those locations, which by extension, are available to all faculty of the College.

Albany Campus

Biosciences Research Building

Most of the ACPHS research laboratories are located in the Biosciences Research Building (BRB), which also houses an animal research facility. The animal facility is licensed by the New York State Department of Health, Laboratory Animal Welfare Program.

Standard equipment such as refrigerated centrifuges, refrigerators, bacteriological and CO2 incubators, -80°C and -20°C freezers, liquid nitrogen storage, power supplies, balances, pH meter, water baths, shaking incubator, hot air ovens, fume hoods, autoclaves ultrapure water purification systems, absorbance and fluorescence plate readers, water baths, shakers, balances and in-house air and water are available throughout the laboratories.

Molecular and microbiological laboratory resources supporting research in cell signaling, infectious disease, DNA, RNA and protein function the BRB include: Class II A2 biosafety cabinets, tissue culture hoods and bacteriological and CO2 incubators, inverted tissue culture microscopes, Quantitative Real-time and traditional PCR machines, gel imaging systems, Western Blot apparatus, an Olympus IX71 Fluorescence Microscope for live cell imaging, a Microm HM 505E cryostat, facilities for Drosophila research including dissection microscopes and fly husbandry, and a Sorvall 6000 super speed centrifuge.

Physiology study resources available in the BRB include: rat-specific Kopf stereotaxic instruments and microinjection equipment for brain studies, an isolated-perfused lung system with a Bio-Pac digital data acquisition module, and a BioPac Hemodynamic systemic monitoring systems for blood pressure studies.

The Organic and Medicinal Chemistry laboratory resources support topical and transdermal drug delivery research as well as chemical synthesis and analysis. The main chemistry lab is equipped with two large fume hoods and adequate bench space to accommodate 5 or 6 researchers working simultaneously. Sample preparation equipment includes a Centrivap concentrator with -84°C cold trap and a high-vacuum pump, shakers, and incubators. There is a dedicated ventilated hood for photochemical reactions equipped to eliminate escape of UV radiation and is protected from incident light. Glassware, stirrers, heating apparatus and other appropriate equipment for chemical synthesis are available. There are multiple chemical and solvent storage units. There is a 6-cell Franz diffusion cell unit equipped with Nicolet FT-IR spectrophotometer and a Shimadzu HPLC system.  

The BRB analytical facility houses a Waters ACQUITY-TQD UPLC-MS/MS system, Waters 600 HPLC system, Hitachi LaChrom Elite HPLC system with PDA detector, analytical balance, and benchtop refrigerated centrifuge. This area also has sample preparation area equipped with pH meter, stirrer, etc. Also available are DLS / zeta potential instrument, a FT-IR spectrometer, Centrivap concentrator with a -84°C cold trap and a high-vacuum pump, dissolution testing apparatus, and large shared -80° C freezers.

O’Brien Building

The O’Brien Building contains the majority of the ACPHS classrooms and teaching laboratories. It also houses several general and organic chemistry and microbiology research laboratories where research in synthetic and medicinal chemistry, neuro and cardiac toxicity, infectious diseases, molecular biology and physiology are conducted. Chemistry resources located in the O’Brien building include a 400 MHz NMR spectrometer, Waters HPLC system with PDA detector and refrigerated autosampler, a MicroCal VP-ITC Isothermal Titration Calorimetry system, and high capacity concentrators.

Molecular Microbiology resources located in the O’Brien building include a BD FACS Verse flow cytometer, conventional and real time PCR systems, gel documentation systems for PCR and western blot, tissue culture and biosafety cabinets, and super speed centrifuges.

Pharmaceutical Research Institute

Founded in 2002 and located in Rensselaer, NY, the Pharmaceutical Research Institute (PRI) is a center for drug discovery and development and houses laboratories with over 10,000 square feet of laboratory space.

PRI investigators have expertise in nanotechnology, medicinal chemistry, molecular biology, and cell biology. Areas of focus include: hematology/oncology, cardiovascular (dyslipidemia), ophthalmology, vascular diseases, neurology, and inflammation.

The PRI Microbiology/Molecular laboratory has Class II A2 biosafety cabinets, bacteriological and CO2 incubators, cell culture facilities, high speed centrifuges, UV/Visible light, fluorescence and spectrophotometer plate readers, and a Leica Microsystems SP5 AOBS UN/405 confocal microscope, along with other standard laboratory equipment. PRI also houses a hematology lab with whole blood aggregometry, thrombelastographs, fibrometers, coagulation analyzer, a Coulter AC-Tdiff-2 analyzer, HPLCs, LC/MS/MS, atomic absorption, and physical and chemical characterization equipment.

Nanotechnology, chemistry, and biotechnology resources at PRI include a zeta size analyzer, atomic force microscope, SEM, GPC, RT PCR, Western blot, and access to microarray, proteomics, and other common equipment. All needed equipment is available for in vivo clinically relevant animal models in the field of thrombosis, cardiovascular, oncology, ophthalmology, and vascular/ neurological disorders, including a surgical microscope, Perkin Elmer IVIS system, and intravitreal imaging.

Other equipment available at PRI includes a Differential Scanning Calorimeter, Powder X-Ray Diffractometer (XRD-6000), Karl Fischer autotitrator, IGASorp Moisture Sorption Analyzer, ES Reach-in stability chamber, and a GPC system.

Vermont Campus

Lab space in the Department of Pharmaceutical Sciences at the Vermont Campus of ACPHS (located in Colchester, VT) has several permanent fixtures including gas, air, water, two fume hoods, a laminar biohood, -20°C and -80°C freezers, Barnstead deionizing water system and an icemaker. A Harris Environmental Cold Room (~80 sq. ft.) provides additional storage and work space for research faculty at a controlled 4°C temperature. Major equipment in the laboratory includes Akta PURIFIER UPC 10 with FRAC-920 Fraction Collector, Thermo Scientific Sorval RC-6+ Centrifuge with two fiberlite rotors, Thermo Scientific Sorval Legend micro-centrifuge, Fisher Scientific digital water bath 5L/10L, New Brunswick Scientific Excella E25R refrigerated incubator/shaker, chromatography refrigerator, Branson Digital Sonifier, Denver Instruments balance, protein and DNA electrophoresis systems and BioRad power supply.

Shared equipment includes: Kinematica HMC-HG 80L Autoclave, nutating mixer and rotating shaker, pH meter, desiccator cabinets, gel UV/VIS light box and digital imaging system, BioRad Western blotting transfer system, micro tube thermal mixer, American Scientific incubator, Barnstead deionizing water system, icemaker, Eppendorf mini centrifuge, Eppendorf Biophotometer, Eppendorf master cycler gradient  real-time PCR machine, Millipore flow cytometer system, multiple freezers and refrigerators, Perkin Elmer PCR system, Nikon microscope, Hitachi Elite LaChrom HPLC system, Innova 4400 double stacked refrigerated incubator/shaker, Mettler Toledo precision balance, Beckman Coulter Allegra 21 centrifuge, Spectra Physics Stopped Flow with UV Visible and fluoresce detection, Cary 5000 UV Vis NIR, Cary Eclipse Fluorimeter, Varian Gas Chromatography/Mass Spectrometry system, laminar biohood, chemical hoods, tissue culture incubator, MicroCal isothermal titration calorimeter, Leica confocal microscope.

Molecular Modeling Laboratory: The departmental computational laboratory seats up to 6 researchers. It is equipped with a Cray CX-1 Linux server, which is connected to 5 Linux workstations locally and 5 Linux workstations remotely. All have dual Xeon quad-core processors, and sufficient memory (144 GB and 24 GB) and graphics capabilities to individually run suites of molecular modeling software, both commercial (Tripos, Schrodinger, ACD, Simulations Plus) and non-commercial (Amber, Charmm, NAMD). Current versions are used for all software, and for commercial software multiple licenses and consultative support are available.